Randy Brill, MD., Ph.D.

Now: Picture taken 2012

Biography
Randy was born in New York, and lived there through High School.  College:   Grinnell, Iowa AB 1949; Medical School, Univ. of Utah, SLC 1956, Graduate School in Berkeley (PhD. Biophysics) 1961; From 1957 -64 he was in the  U.S. Public Health Service. In the PHS he was responsible for  a series of radiation epidemiology studies (including an international multi center study of late effects of I-131).  The first two years in the PHS were in Japan studying leukemia in the A-bomb survivors with Bob Heyssel.  He joined Bob Heyssel at Vanderbilt in 1964, as Assoc. Prof. of Medicine, Radiology and Physics. Together they studied the late effects of Fe-59 in children included in the earlier Hahn studies, along with many studies quantitating tracer metabolism in patients with different diseases.  Many of the studies used the whole body counter, after it was modified to quantify organ uptake and bio distribution. Computer systems were designed and used for instrumentation developments and applications. Methods were developed and applied to teaching, patient management, data acquisition, analysis and imaging applications. New detector materials were used and evaluated for imaging and analysis tasks.

In 1979, after a 1year sabbatical at the University College of London (UCL), Randy moved to Brookhaven National Lab (BNL) in New York, as Sr. Scientist in the Medical Department, Nuclear Medicine Program coordinator, and Prof of Radiology at SUNY, Stony Brook. At BNL his efforts were directed at instrument development, and testing new in vitro and in vivo uses of gamma emitting radiopharmaceuticals and supporting the PET program led by the Chemistry Department. He was the physician responsible   for patient and animal studies at the National Synchrotron Light Source and the Tandem Van der Graff  for studies imaging trace elements in people and biological samples. Studies included phase contrast x-ray imaging, and in vivo cardiovascular imaging using mono energetic x-rays at the National Synchrotron Light Source (NSLS) in collaborations with visiting scientists. A study done in collaboration with Sidney Colowick at Vanderbilt compared the effects of Al on brain glucose metabolism in an Alzheimer disease model.

A dual opposed gamma camera with a 1″ thick NaI crystal previously purchased for imaging the stopping region in the brain in patients irradiated with 200 Mev protons was tested for combined PET and SPECT imaging (UNICON), The absence of programmable digitized electronics on gamma camera components, later available,  precluded combined PET and SPECT imaging applications.

In 1987, when the BNL Research Hospital was closed,  Randy went to the University of Massachusetts in Worcester, as Professor, and Research Director in the Nuclear Medicine Department. In addition to clinical duties, he and  research colleagues carried out a series of radiopharmaceutical  therapy and dosimetry studies. These were done with radiochemists (Hnatowich et al), imaging scientists (King et al), and dosimetrists (Mardirossian, Bushe, and King) and many other talented collaborators (Magne Aas, Aldo Rescigno, Tom Griffin, and visiting scientists from Japan. At Age 69, after ten years, Randy retired, and returned to Vanderbilt.

Since 1997, Randy’s major activities involve  dosimetry research on site with Mike Stabin, and as a member of the SNM MIRD Committee.  Epidemiology studies continue in collaboration with NCI (Thyroid effects of I-131 from Chernobyl and occupational radiation risk studies). He was a member of several National Academy of Sciences Committees analyzing the effects of radioactive fallout; risks to the environment from contamination at  different U.S. Weapons sites; formulating recommendations for compensation to workers  (RECA); as well as National Council on Radiation Protection Committees, the most recent involving Uncertainties in the estimation of radiation risk and the probability of causation.  Most recently, Randy spends much of his time working on a web page on the History of Nuclear Medicine at Vanderbilt, and a study of risks to a million man population of radiation exposed veterans; and another studies on a large NIH cohort of radiology technologists.

1945-49 Grinnell College, A.B. with Honors in Chemistry and Zoology.
1949-52 Graduate Student Physics/Biophysics at Donner Lab, Berkeley, CA.
1952-56 University of Utah Medical School. 1956 M.D.
1956-57 Internal Medicine Internship. Salt Lake General Hospital, Salt Lake City UT.
1957-1964 USPHS Officer. 1957-59 Hiroshima/Nagasaki Japan: Atomic Bomb Casualty Commission (Medicine and Statistics).
1959-61 Research Fellow, University of California, Berkeley. 1961 PhD Biophysics.
1961-64 Assistant Professor Radiology, Johns Hopkins University School of Public Health and Department of Radiology, and Chief Radiation Epidemiology Section, Research Branch, Division of Radiological Health, USPHS, Rockville, MD. PI: USPHS International Cooperative Thyrotoxicosis Therapy Follow-up Study.
1964-72 Associate Professor Medicine, Radiology, Physics, and Biomedical Engineering, Vanderbilt University.
1972 AMA Nuclear Medicine Board Certified
1972-79 Professor Radiology and Physics, Vanderbilt University
1979-87 Sr. Scientist, and Nuclear Medicine Program Coordinator, Brookhaven National Lab, Professor Radiology State University of New York, Stony Brook.
1987-97 Professor Nuclear Medicine,  and Research Director, Department of Nuclear Medicine, University of Massachusetts, Worcester, MA.
1997 Research Professor Radiology and Physics, and Adjunct Professor Biomedical Engineering, Vanderbilt University.

Honors/Awards
National Academy of Sciences Committees:
– Committee on Atomic Casualties (1964-68), BEIR III Comm. (1978-80).
– CDC: Hanford Thyroid Disease Study, Oversight Comm. (1999-2003),
– RECA Committee to Assess Scientific Information for Radiation Exposure Screening and Education Program (2002-2005)

– National Institutes of Health: NCI Chernobyl Study Group (1992-2006).

National Council on Radiation Protection: Committees to assess:
– Risk to Thyroid From Ionizing Radiations (2001-2008);
– Uncertainty in Radiation Risk Estimation (2009-2012)

Society of Nuclear Medicine:
– Chair, Computer Committee: 1970-78 and Council 1978-79:
– Chair, Radiation Effects Ionizing Radiation (REIR) Committee: 1982-90, and

member, Medical Internal Radiation Dose (MIRD) Comm. 1999-present.

Publications

AINGER, L.E., ELY, R.S., DONE, A.K., BRILL, A.B. and KELLEY, V.C. (1955). “Sydenham’s chorea. I. Evidence of abnormal adrenal cortex function,” AMA Am J Dis Child. 89, 575-9.
BUSH, J.A., BERLIN, N.I., JENSEN, W.N., BRILL, A.B., CARTWRIGHT, G.E. and WINTROBE, M.M. (1955). “Erythrocyte life span in growing swine as determined by glycine-2-c14,” J Exp Med. 101, 451-9.

BRILL, A.B, ELY, R.S., DONE, A.K., AINGER, L.E., and KELLEY, V.C. (1956). “Blood adrenocorticotrohin  (ACTH) in children with rheumatic fever,”   J. Clin. End. and Metab. 16: 262-271.

HEYSSEL, R., BRILL, A.B., WOODBURY, L.A., NISHIMURA, E.T., GHOSE, T., HOSHINO, T. and YAMASAKI, M. (1960). “Leukemia in Hiroshima atomic bomb survivors,” Blood. 15, 313-31.

WERNER, S.C., GITTELSOHN, A.M. and BRILL, A.B. (1961). “Leukemia following radioidine therapy of hyperthyroidism,” JAMA. 177, 646-8.

BRILL, A.B., TOMONAGA, M. and HEYSSEL, R.M. (1962). “Leukemia in man following exposure to ionizing radiation. A summary of the findings in Hiroshima and Nagasaki, and a comparison with other human experience,” Ann Intern Med. 56, 590-609.

BRILL, A.B. and FORGOTSON, E.H. (1964). “Radiation and congenital malformations,” Am J Obstet Gynecol. 90, SUPPL:1149-68.

BURROW, G.N., HAMILTON, H.B., HRUBEC, Z., AMAMOTO, K., MATSUNAGA, F. and BRILL, A.B. (1964). “Study of adolescents exposed in utero to the atomic bomb, nagasaki, japan. I. General aspects: Clinical and laboratory data,” Yale J Biol Med. 36, 430-44.

HEYSSEL, R.M., SILVER, L.J., WASSON, M. and BRILL, A.B. (1967). “The relation of blood platelet survival and distribution to 14-c-serotonin distribution and excretion,” Blood. 29, 341-53.
Smith, E.M., and Brill, A.B.:  Progress with computers in medicine.        Nucleonics 25:  5, April 1967.
DYER, N.C., BRILL, A.B., GLASSER, S.R. and GOSS, D.A. (1969). “Maternal-fetal transport and distribution of 59fe and 131-i in humans,” Am J Obstet Gynecol. 103, 290-6.
HAGSTROM, R.M., GLASSER, S.R., BRILL, A.B. and HEYSSEL, R.M. (1969). “Long term effects of radioactive iron administered during human pregnancy,” Am J Epidemiol. 90, 1-10.
SANDSTEAD, H.H., STANT, E.G., BRILL, A.B., ARIAS, L.I. and TERRY, R.T. (1969). “Lead intoxication and the thyroid,” Arch Intern Med. 123, 632-5.
Johnston, R.E., and Brill, A.B.:  Inherent problems in the quantitation of   isotope scan data. Medical Radioisotope Scintigraphy 1: 617‑631, 1969 (IAEA).
Dyer, N.C., and Brill, A.B.:  Fetal radiation dose from maternally             administered Fe‑59 and I‑131, in Radiation Biology of the Fetal and         Juvenile Mammal, Dec. 1969, p. 73‑88.
WOODS, J.W., LIDDLE, G.W., MICHELAKIS, A.M. and BRILL, A.B. (1969). “Effect of an adrenal inhibitor in hypertensive patients with suppressed renin,” Arch Intern Med. 123, 366-70.
ERICKSON, J.J. and BRILL, A.B. (1970). “Digitization of ultrasonic images,” Radiology. 95, 589-93.
SANDSTEAD, H.H., BRILL, A.B., STANT, E.G., JR., LAW, D.H.T. and SCOTT, H.W., JR. (1970). “Effects of jejuno-ileal shunt on body composition in morbidly obese patients,” Surg Forum. 21, 404-6.
MICHELAKIS, A.M., STANT, E.G., JR. and BRILL, A.B. (1971). “Sodium space and electrolyte excretion during the menstrual cycle,” Am J Obstet Gynecol. 109, 150-4.
Brill, A.B., Patton J, Johnston RE, Dyer N, Baglan RJ, Erickson J, Rofes R.  Evaluation of Ge(Li) Detectors for Radioisotope Scanning and  Activation-Analysis Studies. Chapter 8, In Semiconductor Detectors  in the future of nuclear medicine. SNM Press. 1971.
Patton JA, Brill AB, Johnston RE. Potential of Fluorescent Scanning for   Brain-Tumor Identification. Chapter 18. , In Semiconductor Detectors    in the future of nuclear medicine. SNM Press. 1971.
Brill, A.B., Patton, J.A., and Baglan, R.J.:  An experimental comparison of  scintillation and semiconductor detectors for isotope imaging and  counting. IEEE, Nuclear Science, Vol. NS‑19, #3, 179‑189, June    1972.
Dyer, N.C., and Brill, A.B.:  Use of the stable tracers Fe‑58 and Cr‑50 for the     study of iron utilization in pregnant women. Nuclear Activation  Techniques in the Life Sciences. IAEA, pp. 469‑477, 1972.
Brill, A.B., Patton, J.A., Price, R.R., and Flanigan Kosik, C.V.: Applications  of high resolution semi‑conductor detectors in the evaluation of  tumor‑localizing tracers.  Monte Carlo Symposium, October 23‑28, 1972, in Medical Radioisotope Scintigraphy, I, 217‑240, IAEA, Vienna.
Patton, J.A., Brill, A.B., King, P.H.:  A new mode of collection and display  of three dimensional data for static and dynamic radiotracer studies.   Monte Carlo Symposium, October 23‑28, 1972, in Medical  Radioisotope Scintigraphy, I, 355‑368, IAEA, Vienna, 1972.
SCOTT, H.W., JR., SANDSTEAD, H.H., BRILL, A.B., BURKO, H. and YOUNGER, R.K. (1971). “Experience with a new technic of intestinal bypass in the treatment of morbid obesity,” Ann Surg. 174, 560-72.
STAAB, E.V., BABB, O.A., KLATTE, E.C. and BRILL, A.B. (1971). “Pancreatic radionuclide imaging using electronic subtraction technique,” Radiology. 99, 633-40.
BRAHMAVAR, S.M., GROVES, R.B., STAAB, E.V., ERICKSON, J.J. and BRILL, A.B. (1972). “Optimization of data in lung and brain scans,” J Nucl Med. 13, 881-4.
BRILL, A.B., SANDSTEAD, H.H., PRICE, R., JOHNSTON, R.E., LAW, D.H.T. and SCOTT, H.W., JR. (1972). “Changes in body composition after jejunoileal bypass in morbidity obese patients,” Am J Surg. 123, 49-56.
DYER, N.C. and BRILL, A.B. (1972). “Maternal-fetal transport of iron and iodine in human subjects,” Adv Exp Med Biol. 27, 351-66.
JOHNSTON, R.E., STAAB, E.V., BRILL, A.B. and ALLEN, J.H. (1972). “Radiation dosimetry associated with the intrathecal administration of 131 i human serum albumin,” Br J Radiol. 45, 444-51.
LUBOZYNSKI, M.F., BAGLAN, R.J., DYER, G.R. and BRILL, A.B. (1972). “Sensitivity of x-ray fluorescence for trace element determinations in biological tissues,” Int J Appl Radiat Isot. 23, 487-91.
WATTS, J.R., ERICKSON, J.J., KRAMER, C.E., JOHNSTON, R.E., LAGAN, J.E., BAGLAN, R.J. and BRILL, A.B. (1972). “Design and evaluation of a scanning-bed wholebody counter for use in clinical studies,” Health Phys. 23, 63-6.
BRILL, A.B. and ERICKSON, J.J. (1973). “Factors affecting the collection and analysis of radiotracer images,” Semin Nucl Med. 3, 285-300.
Price, R.R., Johnston, R.E., Brill, A.B., and Watts, J.R.:  Estimation of      radioactive content of body organs combining direct measurements   and distribution models.  Proceedings of the Symposium on the   Assessment of Radioactive Organ and Body Burdens, held in  Stockholm, Sweden, Nov. 22‑26, 1971, IAEA/WHO, pp. 45‑57,         Vienna, 1972.
Erickson, J.J., Eastwold, E.L., Parker, J.D., Baglan, R.J., Larsen, K.H., and  Brill, A.B.:  Two inexpensive automatic sample changes for use with  an MCA. Nuclear Instruments and Methods 112:597‑599, 1973.
Dyer, N.C., Brill, A.B., Raye, J., Gutberlet, R., and Stahlman, M.:             Maternal‑fetal exchange of Fe‑59:  Radiation dosimetry and             biokinetics in human and sheep studies. Radiol Res 53: 488‑495,         1973.
Brill, A.B., Baglan, R.J., Fleet, W., Schaffner, W., Schulert, A. “A Network  to Determine the Causality Between Abnormal Trace Levels and Congenital Defects,” NSF‑RANN Trace Contaminants Abstracts, Toxic Materials Information Center, Environmental Information System Office, ORNL, August 1973.
Ivancevic, D., Price, R.R., Rhea, T., Graham, T.P., Atwood, G.F., and Brill,  A.B.:  Computer analysis of radiocardiograms of patients with   intracardiac shunts. Proceedings of IAEA Symposium on Dynamic       Studies with Radioisotopes in Clinical Medicine and Research, 1974.   IAEA‑SM‑185/28, 229‑250.  Knoxville, Tennessee (1974).
Price, R.R., McKee, L.C., Jr., Krantz, S.B., and Brill, A.B. Estimation of    slow dynamic function parameters in iron kinetics studies using         quantitative measurements and compartmental modeling     analysis.  Proceedings IAEA Symposium on Dynamic Studies with         Radioisotope in Clinical Medicine Research. 1974. IAEA‑SM‑185/38,     429‑444.
Hollifield, J.W., Brill, A.B.:  Low 17‑Ketosteroid level, hypokalemia, and wasting after obesity surgery. JAMA 230 (6): 900, Nov. 11, 1974.
Baglan, R.J., Brill, A.B., Schulert, D., Larsen, W.K., Dyer, N., Mansour, M., Schaffner, W., Hoffman, L., and Davies, J.:  Utility of placental tissue  as an indicator of trace element exposure to adult and fetus. Environ.  Res. 8:  64‑70, 1974.
Brill, A.B.:  Data‑handling systems for use in dynamic function studies. In Dynamic Studies with Radioisotopes in Medicine 1974. Vol. 1,  International Atomic Energy Agency, Vienna, 1974, pp. 13‑24.
Jones, J.P., Wagner, J., and Brill, A.B.:  An in vivo evaluation of standard  man model absorbed fractions using TC‑Sulfur Colloid.          Radiopharmaceutical Dosimetry Symposium, Oak Ridge, TN          April 26‑29, p. 283‑289, 1976.
Price, R.R., Wagner, J., Larsen, K.H., Patton, J.A., Touya, J.J., and Brill,   A.B.:  Techniques for measuring regional and total‑body bone mineral     mass to bone function ratios. In Medical Radionuclide Imaging, Vol.  2, Proceedings of a Symposium. Los Angeles, October 25‑29, 1976.   IAEA SM‑210/64, 145‑158, Vienna.

 

Patton, J.A., Price, R.R., Brill, A.B., and Pehl, R.:  A Mosaic Intrinsic         Germanium Radioisotope Scanning Device with Longitudinal Section scanning Capability. In Medical Radionuclide Imaging, Vol. 1,  Proceedings of a Symposium. Los Angeles, October 25‑29, 1976.      IAEA‑SM‑210/165, 159‑169.

Yonekura, Y., Brill, A.B., Som, P., Yamamoto, K., Srivastava, S.C., Iwai, J.,   Elmaleh, D.R., Livni, E., Strauss, H.W., Goodman, M.M., Knapp,         F.F., Jr. Regional Myocardial Substrate Uptake in Hypertensive Rats:   A Quantitative Autoradiographic Measurement Science, Vol. 227,         1494‑1496, March 1985.

Parker, F.L., Brill, A.G., Grimes, W.R., Kahn, B., Jacobs, D.G., Watson,         E.C.: The Potential Consequences of Tritium and other Isotopes         Discharged in Treated Three Mile Island Accident Generated     Waste  Waters. NCRP Report of SC‑38, Task Group on Accident Generated  Waste Water, 1985.

Dilmanian FA, Weber DA, Coderre JA, Joel DD, Shi K-C, Meinken GE,         Som P, Tang Y-N, Volkow ND, Yee C, Brill AB:  A high resolution  SPECT system based on a microchannel-plate imager.  IEEE Trans  Nucl Sci 37:687-695, 1990.

Cinotti, L., Bazzin, J.P., DiPaola, R., Susskind, H., and Brill, A.B.              Processing of Xe-127 regional pulmonary ventilation by factor             analysis and compartmental modeling.  IEEE Trans Med Imaging         10:3, 437-444, 1991.

Rescigno A, Brill AB, Bushe H, Hnatowich DJ:  On compartment             biodistribution.  Nucl Med Biol 18:367, 1991 (Letter).

Griffin, T., Brill, B., Bokhari, F., Bernier, M., Collins, J., Stochl, M., Gionet,    M., Ruschowski, M., Siebecker, D., Stroup, S., Kiefer, H., Sumerdon,   G., Johnson, D., Wilson, J., Hnatowich, D.  A pharmacokinetic and   clinical study of the AB2 anti-CEA antibody in patients with   colorectal carcinoma.  Proceedings of the Second Conference on the   Radioimmunodetection and Radioimmunotherapy of Cancer, May,         1989

Ito T, Griffin TW, Collins JA, Brill AB:  Immunotoxin (IT) penetration into   tumor foci assessed by quantitative autoradiography.  Proc of Second International Symposium on Immunotoxins.  June 14-16, 1990.  Lake   Buena Vista, FL.

Hnatowich DJ, Hunter R, Griffin T, Stevens S, Mardirossian G, Kinders RJ,    Rusckowski M, Rose P, Brill AB.  Intraperitoneal therapy of ovarian  cancer with yttrium-90 labeled monoclonal antibodies.  Ant  Immunology and Radiopharm 3:40, 1990.

Siegel JA, Wessels BA, Watson EE, Stabin MG, Vriesendorp HM, Bradley  EW, Badger CC, Brill AB, Kwok CS, Stickney DR, Eckerman KF, Fisher DR, Buchsbaum DJ, Order SE:  Summary report of the AAPM  Nuclear Medicine Task Force on bone marrow dosimetry and toxicity   for radioimmunotherapy.  Ant Immunoconj and Radiopharm 3:77, 1990.

AAS, M., MARDIROSSIAN, G., GRIFFIN, T.W., SALIMI, A.R., ITO, T., BUSHE, H.S., ATCHER, R.W., HINES, J.J., BRILL, A.B. and HNATOWICH, D.J. (1992). “Long-term biodistribution in tumored mice of murine and chimeric b72.3-igg antibody radiolabeled with 114min via both dtpa and a macrocyclic chelator,” J Nucl Biol Med. 36, 33-40.
ITO, T., GRIFFIN, T.W., COLLINS, J.A. and BRILL, A.B. (1992). “Intratumoral and whole-body distributions of c110 anti-carcinoembryonic antigen radioimmunotoxin after intraperitoneal and intravenous injection: A quantitative autoradiographic study,” Cancer Res. 52, 1961-7.
HNATOWICH, D.J., MARDIROSSIAN, G., RUSCKOWSKI, M., ROY, S., BUSHE, H., GRIFFIN, T.W. and BRILL, A.B. (1993). “Pharmacokinetics of the fo23c5 anti-cea antibody fragment labelled with 99tcm and 111in: A comparison in patients,” Nucl Med Commun. 14, 52-63.
ROESKE, J.C., CHEN, G.T. and BRILL, A.B. (1993). “Dosimetry of intraperitoneally administered radiolabeled antibodies,” Med Phys. 20, 593-600.
BRILL, A.B., BECKER, D.V., DONAHOE, K., GOLDSMITH, S.J., GREENSPAN, B., KASE, K., ROYAL, H., SILBERSTEIN, E.B. and WEBSTER, E.W. (1994). “Radon update: Facts concerning environmental radon: Levels, mitigation strategies, dosimetry, effects and guidelines. Snm committee on radiobiological effects of ionizing radiation,” J Nucl Med. 35, 368-85.
MATSUSHITA, T., GRIFFIN, T.W., YAO, Z., DELICHATSIOS, H. and BRILL, A.B. (1994). “Human recombinant tnf-alpha on localization of 90y-radioantibody in human tumour xenografts,” Ther Immunol. 1, 71-6.
Brill AB, Hull A. Post-Chernobyl Thyroid Cancer Study Under Way. Health   Physics Society Newsletter. Nov. 1994, 18-19.
DONOHOE, K.J., BRILL, A.B., BRILL, D.R., CONWAY, J.J., SILBERSTEIN, E.B. and WHIPPLE, C. (1996). “How to be an effective risk communicator,” J Nucl Med. 37, 20N-22N.
DONOHOE, K.J., BRILL, A.B., BRILL, D.R., CONWAY, J.J., SILBERSTEIN, E.B. and WHIPPLE, C. (1996). “How to be an effective risk communicator–part 1,” J Nucl Med. 37, 23N-6N.
MARDIROSSIAN, G., BRILL, A.B., DWYER, K.M., KAHN, D. and NELP, W. (1996). “Radiation absorbed dose from indium-111-cyt-356,” J Nucl Med. 37, 1583-8.
SCHWENN, M.R. and BRILL, A.B. (1997). “Childhood cancer 10 years after the chernobyl accident,” Curr Opin Pediatr. 9, 51-4.
Ljungberg MI, King MA, Danfelter M, Strand SE, and Brill AB. Scatter   Correction in   Scintillation Camera Imaging of Positron-emitting         Radionuclides. Presented at Nov. 1996 IEEE  NPSS Medical Imaging         Conference.
Brill AB, Anspaugh L, Eckerman K, Stabin M. Radioactive Iodine Dose to     the Breast and Thyroid in Lactating Women and Nursing Infants from   the Chernobyl Accident. Presented at Mayo Clinic International    Symposium on Radiodine. Aug 24-27 1996. In, The Thyroid. (April   1997).
Brill, A.B. Radiation and the Environment. In Our Natural Environment:         Concepts and Solutions. In Proceedings of the Second International         Interdisciplinary Conference on the Environment. Newport, RI. June         15-19, 1996. Ed. KL Hickey and D. Kantarelis.
Brill, A.B. Radiobiologic Consequences of I-131. What we know, and may         learn from the          Chernobyl Accident. In Proceedings of Second         International Congress of the Croatian Society of Nuclear Medicine.         Presented 24 Oct. 1996
MARDIROSSIAN, G., BRILL, A.B., HARWOOD, S.J., OLSEN, J., DWYER, K.A. and SIEGEL, J.A. (1998). “Radiation absorbed dose estimates for indium-111-labeled b72.3, an IGG antibody to ovarian and colorectal cancer: Mird dose estimate report no. 18,” J Nucl Med. 39, 671-6.
RON, E., DOODY, M.M., BECKER, D.V., BRILL, A.B., CURTIS, R.E., GOLDMAN, M.B., HARRIS, B.S., 3RD, HOFFMAN, D.A., MCCONAHEY, W.M., MAXON, H.R., PRESTON-MARTIN, S., WARSHAUER, M.E., WONG, F.L. and BOICE, J.D., JR. (1998). “Cancer mortality following treatment for adult hyperthyroidism. Cooperative thyrotoxicosis therapy follow-up study group,” JAMA. 280, 347-55.
BOLCH, W.E., BOUCHET, L.G., ROBERTSON, J.S., WESSELS, B.W., SIEGEL, J.A., HOWELL, R.W., ERDI, A.K., AYDOGAN, B., COSTES, S., WATSON, E.E., BRILL, A.B., CHARKES, N.D., FISHER, D.R., HAYS, M.T. and THOMAS, S.R. (1999). “Mird pamphlet no. 17: The dosimetry of nonuniform activity distributions–radionuclide s values at the voxel level. Medical internal radiation dose committee,” J Nucl Med. 40, 11S-36S.
HOWELL, R.W., WESSELS, B.W., LOEVINGER, R., WATSON, E.E., BOLCH, W.E., BRILL, A.B., CHARKES, N.D., FISHER, D.R., HAYS, M.T., ROBERTSON, J.S., SIEGEL, J.A. and THOMAS, S.R. (1999). “The mird perspective 1999. Medical internal radiation dose committee,” J Nucl Med. 40, 3S-10S.
MARDIROSSIAN, G., TAGESSON, M., BLANCO, P., BOUCHET, L.G., STABIN, M., YORIYAZ, H., BAZA, S., LJUNGBERG, M., STRAND, S.E. and BRILL, A.B. (1999). “A new rectal model for dosimetry applications,” J Nucl Med. 40, 1524-31.
SIEGEL, J.A., THOMAS, S.R., STUBBS, J.B., STABIN, M.G., HAYS, M.T., KORAL, K.F., ROBERTSON, J.S., HOWELL, R.W., WESSELS, B.W., FISHER, D.R., WEBER, D.A. and BRILL, A.B. (1999). “Mird pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates,” J Nucl Med. 40, 37S-61S.
SGOUROS, G., STABIN, M., ERDI, Y., AKABANI, G., KWOK, C., BRILL, A.B. and WESSELS, B. (2000). “Red marrow dosimetry for radiolabeled antibodies that bind to marrow, bone, or blood components,” Med Phys. 27, 2150-64.
WELLS, R.G., KING, M.A., SIMKIN, P.H., JUDY, P.F., BRILL, A.B., GIFFORD, H.C., LICHO, R., PRETORIUS, P.H., SCHNEIDER, P.B. and SELDIN, D.W. (2000). “Comparing filtered back projection and ordered-subsets expectation maximization for small-lesion detection and localization in 67Ga SPECT ,” J Nucl Med. 41, 1391-9.
STABIN, M.G. and BRILL, A.B. (2001). “Monoclonal antibodies in the treatment of hematologic malignancies: Radiation dosimetry aspects,” Curr Pharm Biotechnol. 2, 351-6.
DI MARTINO, F., TRAINO, A.C., BRILL, A.B., STABIN, M.G. and LAZZER, M.         (2002). “A theoretical model for prescription of the patient-specific             therapeutic activity for radioiodine therapy of graves’ disease,” Phys Med         Biol. 47, 1493-9.
SIEGEL, J.A., STABIN, M.G. and BRILL, A.B. (2002). “The importance of patient-specific radiation dose calculations for the administration of radionuclides in therapy,” Cell Mol Biol (Noisy-le-grand). 48, 451-9.
STABIN, M. and BRILL, A.B. (2003). “Physics in nuclear medicine: A year of tangible progress,” J Nucl Med. 44, 22N-25N.
STEZHKO, V.A., BUGLOVA, E.E., DANILOVA, L.I., DROZD, V.M., KRYSENKO, N.A., LESNIKOVA, N.R., MINENKO, V.F., OSTAPENKO, V.A., PETRENKO, S.V., POLYANSKAYA, O.N., RZHEUTSKI, V.A., TRONKO, M.D., BOBYLYOVA, O.O., BOGDANOVA, T.I., EPHSTEIN, O.V., KAIRO, I.A., KOSTIN, O.V., LIKHTAREV, I.A., MARKOV, V.V., OLIYNIK, V.A., SHPAK, V.M., TERESHCHENKO, V.P., ZAMOTAYEVA, G.A., BEEBE, G.W., BOUVILLE, A.C., BRILL, A.B., BURCH, J.D., FINK, D.J., GREENEBAUM, E., HOWE, G.R., LUCKYANOV, N.K., MASNYK, I.J., MCCONNELL, R.J., ROBBINS, J., THOMAS, T.L., VOILLEQUE, P.G. and ZABLOTSKA, L.B. (2004). “A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: Objectives, design and methods,” Radiat Res. 161, 481-92.
LYSHCHIK, A., HIGASHI, T., ASATO, R., TANAKA, S., ITO, J., HIRAOKA, M., BRILL, A.B., SAGA, T. and TOGASHI, K. (2005). “Elastic moduli of thyroid tissues under compression,” Ultrason Imaging. 27, 101-10.
LYSHCHIK, A., HIGASHI, T., ASATO, R., TANAKA, S., ITO, J., MAI, J.J., PELLOT-BARAKAT, C., INSANA, M.F., BRILL, A.B., SAGA, T., HIRAOKA, M. and TOGASHI, K. (2005). “Thyroid gland tumor diagnosis at us elastography,” Radiology. 237, 202-11.
STABIN, N. and BRILL, A.B. (2005). “Physics applications in nuclear medicine: Progress on many fronts,” J Nucl Med. 46, 16N, 19N-20N, 22N.
BOICE, J.D., COHEN, S.S., MUMMA, M.T., DUPREE ELLIS, E., ECKERMAN, K.F., LEGGETT, R.W., BOECKER, B.B., BRILL, A.B. and HENDERSON, B.E. (2006). “Mortality among radiation workers at rocketdyne (atomics international), 1948-1999,” Radiat Res. 166, 98-115.
Jackson H, Brill AB, Nurdan K, Peterson TE, Walenta AH. MonteCarlo         simulations for design optimization of a Compton camera imager for         dosimetry in radionuclide therapy. In IEEE NPSS Conference             Proceedings, Nov.2007.
N YH, Xu XG, Lyshchik A, Brill AB. 3D ultrasound model based             segmentation and volume measurement methods: Thyroid phantom         and clinical study. In IEEE NPSS Conference Proceedings, Nov.2007.
BOICE, J.D., JR., LEGGETT, R.W., ELLIS, E.D., WALLACE, P.W., MUMMA, M., COHEN, S.S., BRILL, A.B., CHADDA, B., BOECKER, B.B., YODER, R.C. and ECKERMAN, K.F. (2006). “A comprehensive dose reconstruction methodology for former rocketdyne/atomics international radiation workers,” Health Phys. 90, 409-30.
BOICE, J.D., JR., MARANO, D.E., COHEN, S.S., MUMMA, M.T., BLOT, W.J., BRILL, A.B., FRYZEK, J.P., HENDERSON, B.E. and MCLAUGHLIN, J.K. (2006). “Mortality among rocketdyne workers who tested rocket engines, 1948-1999,” J Occup Environ Med. 48, 1070-92.
BRILL, A.B., STABIN, M., BOUVILLE, A. and RON, E. (2006). “Normal organ radiation dosimetry and associated uncertainties in nuclear medicine, with emphasis on iodine-131,” Radiat Res. 166, 128-40.
TRONKO, M.D., BRENNER, A.V., OLIJNYK, V.A., ROBBINS, J., EPSTEIN, O.V., MCCONNELL, R.J., BOGDANOVA, T.I., FINK, D.J., LIKHTAREV, I.A., LUBIN, J.H., MARKOV, V.V., BOUVILLE, A.C., TEREKHOVA, G.M., ZABLOTSKA, L.B., SHPAK, V.M., BRILL, A.B., TERESHCHENKO, V.P., MASNYK, I.J., RON, E., HATCH, M. and HOWE, G.R. (2006). “Autoimmune thyroiditis and exposure to iodine 131 in the ukrainian cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: Results from the first screening cycle (1998-2000),” J Clin Endocrinol Metab. 91, 4344-51.
TRONKO, M.D., HOWE, G.R., BOGDANOVA, T.I., BOUVILLE, A.C., EPSTEIN, O.V., BRILL, A.B., LIKHTAREV, I.A., FINK, D.J., MARKOV, V.V., GREENEBAUM, E., OLIJNYK, V.A., MASNYK, I.J., SHPAK, V.M., MCCONNELL, R.J., TERESHCHENKO, V.P., ROBBINS, J., ZVINCHUK, O.V., ZABLOTSKA, L.B., HATCH, M., LUCKYANOV, N.K., RON, E., THOMAS, T.L., VOILLEQUE, P.G. and BEEBE, G.W. (2006). “A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: Thyroid cancer in ukraine detected during first screening,” J Natl Cancer Inst. 98, 897-903.
LYSHCHIK, A., HIGASHI, T., ASATO, R., TANAKA, S., ITO, J., HIRAOKA, M., INSANA, M.F., BRILL, A.B., SAGA, T. and TOGASHI, K. (2007). “Cervical lymph node metastases: Diagnosis at sonoelastography–initial experience,” Radiology. 243, 258-67.
MCCONNELL, R.J., BRENNER, A.V., OLIYNYK, V.A., ROBBINS, J., TEREKHOVA, G.M., FINK, D.J., EPSHTEIN, O.V., HATCH, M., SHPAK, V.M., BRILL, A.B., SHELKOVOY, Y.A., ZABLOTSKA, L.B., MASNYK, I.J., HOWE, G.R. and TRONKO, M.D. (2007). “Factors associated with elevated serum concentrations of anti-tpo antibodies in subjects with and without diffuse goitre. Results from the ukrainian-american cohort study of thyroid cancer and other thyroid diseases following the chornobyl accident,” Clin Endocrinol (Oxf). 67, 879-90.
STABIN, M. and BRILL, A.B. (2007). “Physics applications in nuclear medicine: Carpe photon,” J Nucl Med. 48, 35N-38N.
BRILL, A.B. (2008). “Mird recognizes Atkins with Loevinger-Berman award,” J Nucl Med. 49, 34N.
LIU, S., KING, M.A., BRILL, A.B., STABIN, M.G. and FARNCOMBE, T.H. (2008). “Convolution-based forced detection monte carlo simulation incorporating septal penetration modeling,” IEEE Trans Nucl Sci. 55, 967-974.
LIU, S., KING, M.A., BRILL, A.B., STABIN, M.G. and FARNCOMBE, T.H. (2008). “Accelerated spect monte carlo simulation using multiple projection sampling and convolution-based forced detection,” IEEE Trans Nucl Sci. 55, 560-567.
STABIN, M. and BRILL, A.B. (2008). “Physics applications in nuclear medicine: 2007,” J Nucl Med. 49, 20N-5N.
STABIN, M.G. and BRILL, A.B. (2008). “State of the art in nuclear medicine dose assessment,” Semin Nucl Med. 38, 308-20.
STABIN, M.G. and BRILL, A.B. (2008). “Radiation dosimetry and exposure in nuclear medicine,” Semin Nucl Med. 38, 306-7.
VICINI, P., BRILL, A.B., STABIN, M.G. and RESCIGNO, A. (2008). “Kinetic modeling in support of radionuclide dose assessment,” Semin Nucl Med. 38, 335-46.
WESSELS, B.W., KONIJNENBERG, M.W., DALE, R.G., BREITZ, H.B., CREMONESI, M., MEREDITH, R.F., GREEN, A.J., BOUCHET, L.G., BRILL, A.B., BOLCH, W.E., SGOUROS, G. and THOMAS, S.R. (2008). “Mird pamphlet no. 20: The effect of model assumptions on kidney dosimetry and response–implications for radionuclide therapy,” J Nucl Med. 49, 1884-99.
ZABLOTSKA, L.B., BOGDANOVA, T.I., RON, E., EPSTEIN, O.V., ROBBINS, J., LIKHTAREV, I.A., HATCH, M., MARKOV, V.V., BOUVILLE, A.C., OLIJNYK, V.A., MCCONNELL, R.J., SHPAK, V.M., BRENNER, A., TEREKHOVA, G.N., GREENEBAUM, E., TERESHCHENKO, V.P., FINK, D.J., BRILL, A.B., ZAMOTAYEVA, G.A., MASNYK, I.J., HOWE, G.R. and TRONKO, M.D. (2008). “A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: Dose-response analysis of thyroid follicular adenomas detected during first screening in ukraine (1998-2000),” Am J Epidemiol. 167, 305-12.
STABIN, M. and BRILL, A.B. (2009). “Physics applications in nuclear medicine: 2008 in review,” J Nucl Med. 50, 17N-21N.
CLARK, L.D., STABIN, M.G., FERNALD, M.J. and BRILL, A.B. (2010). “Changes in radiation dose with variations in human anatomy: Moderately and severely obese adults,” J Nucl Med. 51, 929-32.
MARINE, P.M., STABIN, M.G., FERNALD, M.J. and BRILL, A.B. (2010). “Changes in radiation dose with variations in human anatomy: Larger and smaller normal-stature adults,” J Nucl Med. 51, 806-11.
SGOUROS, G., ROESKE, J.C., MCDEVITT, M.R., PALM, S., ALLEN, B.J., FISHER, D.R., BRILL, A.B., SONG, H., HOWELL, R.W., AKABANI, G., BOLCH, W.E., MEREDITH, R.F., WESSELS, B.W. and ZANZONICO, P.B. (2010). “Mird pamphlet no. 22 (abridged): Radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy,” J Nucl Med. 51, 311-28.
BOICE, J.D., JR., COHEN, S.S., MUMMA, M.T., ELLIS, E.D., ECKERMAN, K.F., LEGGETT, R.W., BOECKER, B.B., BRILL, A.B. and HENDERSON, B.E. (2011). “Updated mortality analysis of radiation workers at rocketdyne (atomics international), 1948-2008,” Radiat Res. 176, 244-58.
DEWARAJA, Y.K., FREY, E.C., SGOUROS, G., BRILL, A.B., ROBERSON, P., ZANZONICO, P.B. and LJUNGBERG, M. (2012). “Mird pamphlet no. 23: Quantitative spect for patient-specific 3-dimensional dosimetry in internal radionuclide therapy,” J Nucl Med. 53, 1310-25.
Peterson TE, Brill AB, Walenta AH. High Energy Gamma-Ray Imaging         Using Cherenkov Cone Detection – A Monte Carlo Study with             Application to a Compton Camera System. Presented at IEEE Nuclear        Science Symposium and Medical Imaging Conference, Annaheim,         California. 17 Oct -3 Nov. 2012.
Preston, R. J., J. D. Boice, A. B. Brill, R. Chakraborty, R. Connolly, F. O.   Hoffman, R. W. Hornung, D. C. Kocher, C. E. Land, R. E. Shore and         G. E. Woloschak (2013). “MEMORANDUM.  Uncertainties in             estimating health risks associated with exposure to ionising             radiation. .” J. Radiol. Prot. 13.